长期生存的多发性骨髓瘤患者免疫指标分析

niwanmao

这篇文献用流式细胞术检测了长期存活的多发性骨髓瘤（MM）患者与初发MGUS、有症状的MM患者。主要检测了CD8＋细胞毒T细胞、NK细胞、Treg、B细胞、树突状细胞等免疫系统指标，长期存活的MM患者中均高于其它两类患者，提示免疫机制对MM患者长期存活的重要性。<br><br><b><font size="4">Analysis of the immune system of multiple myeloma patients achieving long-term disease control, by multidimensional flow cytometry.</font></b><br>Pessoa-Magalhaes RJ&nbsp; &nbsp;, Vidriales MB&nbsp; &nbsp;, Paiva B&nbsp; &nbsp;, Gimenez CF&nbsp; &nbsp;, Garcia-Sanz R&nbsp; &nbsp;, Mateos MV&nbsp; &nbsp;, Gutierrez N&nbsp; &nbsp;, Lecrevisse Q&nbsp; &nbsp;, Blanco JF&nbsp; &nbsp;, Hernandez J&nbsp; &nbsp;, de Las Heras N&nbsp; &nbsp;, Martinez J&nbsp; &nbsp;, Roig M&nbsp; &nbsp;, da Costa ES&nbsp; &nbsp;, Ocio E&nbsp; &nbsp;, Perez-Andres M&nbsp; &nbsp;, Maiolino A&nbsp; &nbsp;, Nucci M&nbsp; &nbsp;, Delarubia J&nbsp; &nbsp;, Lahuerta JJ&nbsp; &nbsp;, San Miguel JF&nbsp; &nbsp;, Orfao A <br><br>Haematologica. 2012 Jul 6. [Epub ahead of print]<br><br><b><font size="3">Abstract</font></b><br>Background. Multiple myeloma remains largely incurable. However, a few patients experience ≥10-years relapse-free survival and can be considered as operationally cured. Interestingly, long-term disease control in multiple myeloma is not restricted to patients with complete response, since some revert into an MGUS profile. Design and Methods. We compared the distribution of multiple compartments of lymphocytes and dendritic cells in the bone marrow and peripheral blood of long-term disease control multiple myeloma (n=28) vs. both newly-diagnosed MGUS (n=23) and symptomatic multiple myeloma (n=23), and age-matched healthy adults (n=10). Results. Similarly to MGUS and symptomatic multiple myeloma, patients with long-term disease control showed an expansion of cytotoxic CD8+T-cells and NK-cells. However, bone marrow Tregs were reduced in long-term disease control vs. symptomatic multiple myeloma. Noteworthy, B-cells were depleted in MGUS and symptomatic multiple myeloma, while recovered in long-term disease control patients in both bone marrow and peripheral blood, due to an increase in normal bone marrow B-cell precursors and plasma cells, as well as pre-germinal center peripheral blood B-cells. The number of bone marrow dendritic cells and tissue macrophages significantly differed between long-term disease control and symptomatic multiple myeloma with a recovery trend in the former patient population towards levels similar to those found in healthy adults.Conclusions. In summary, our results indicate that long-term disease control multiple myeloma patients have a constellation of unique immune changes favoring both immune cytotoxicity and recovery of B-cell production and homing, suggesting an improved immunesurveillance.Keywords: myeloma, long term follow-up, immunesurveillance, T-cells, Tregs, B-cells.<br><br><br><br>PDF附件见： immun_system_MM.pdf (1.36 MB, 下载次数: 12, 售价: 2 流星)

2012-7-16 11:54 上传

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