Treg与抗肿瘤免疫

huzengwu

http://www.ncbi.nlm.nih.gov/pubmed/22806892


Depletion of radio-resistant regulatory T cells enhances antitumor immunity during recovery from lymphopenia.
Baba J, Watanabe S, Saida Y, Tanaka T, Miyabayashi T, Koshio J, Ichikawa K, Nozaki K, Koya T, Deguchi K, Tan C, Miura S, Tanaka H, Tanaka J, Kagamu H, Yoshizawa H, Nakata K, Narita I.

SourceDepartment of Medicine (II), Niigata University Medical and Dental Hospital, Niigata, Japan;


AbstractCytotoxic lymphodepletion therapies augment antitumor immune responses. The generation and therapeutic efficacy of antitumor effector T cells (T(E)s) are enhanced during recovery from lymphopenia. Although the effects of lymphodepletion on naïve T cells (T(N)s) and T(E)s have been studied extensively, the influence of lymphodepletion on suppressor cells remains poorly understood. In this study, we demonstrate a significant increase of CD4(+)CD25(+)Foxp3(+) regulatory T cells (Treg) in sublethally irradiated lymphopenic mice. These radio-resistant Treg inhibited the induction of T(E)s in tumor-draining lymph-nodes (TDLNs) during recovery from lymphopenia. The transfer of T(N)s into lymphopenic tumor-bearing mice resulted in some antitumor effects; however, Treg depletion after whole-body irradiation and reconstitution strongly inhibited tumor progression. Further analyses revealed that tumor-specific T cells were primed from the transferred T(N)s, whereas the Treg originated from irradiated recipient cells. As in irradiated lymphopenic mice, a high percentage of Treg was observed in cyclophosphamide-treated lymphopenic mice. The inhibition of Treg in cyclophosphamide-treated mice significantly reduced tumor growth. These results indicate that the Treg that survive cytotoxic therapies suppress antitumor immunity during recovery from lymphopenia and suggest that approaches to deplete radio-and chemo-resistant Treg can enhance cancer immunotherapies

huzengwu

http://www.ncbi.nlm.nih.gov/pubmed/22806892网址
能弄到全文就好了

niwanmao

<div class="quote"><blockquote><font size="2"><font color="#999999">huzengwu 发表于 2012-7-19 21:06</font> <a href="forum.php?mod=redirect&amp;goto=findpost&amp;pid=7018&amp;ptid=1720" target="_blank"><img src="static/image/common/back.gif" border="0" alt="" style="max-width:400px"></a></font>
http://www.ncbi.nlm.nih.gov/pubmed/22806892网址
能弄到全文就好了</blockquote></div>
<div>全文已下载，还没正式出版，还是manuscript的形式。</div><div><br></div><div>肿瘤免疫方面的治疗研究确实很热门。</div><div><br></div><p></p>
PDF附件见：&nbsp; Depletion_of_radio-resistant_regulatory_T_cells.pdf (1.98 MB, 下载次数: 19, 售价: 2 流星)

2012-7-20 10:13 上传

点击文件名下载附件

，下载需要2颗流星（<a href="http://www.flowcyto.cn/bbs/forum.php?mod=viewthread&amp;tid=1520" target="_blank">为什么？</a>）
<br>
使用流式中文网资料阅读器在线阅读，免流星，内容完全一样（<b>IE8和360浏览器无法显示，建议使用IE9和google chrome浏览器。</b><a href="http://www.flowcyto.cn/bbs/forum.php?mod=viewthread&amp;tid=1527" target="_blank">使用说明</a>）
<br>
<script type="text/javascript" src="flash/flowcytoview/swfobject.js"></script>
   <script type="text/javascript">
                        function thisMovie(movieName) {
                         if (navigator.appName.indexOf("Microsoft") != -1) {
                                 return window[movieName];
                         } else {
                                 return document[movieName];
                         }
                         }

                        function SaveState(){
                        thisMovie("flowcytoView").SaveState();
                        }

                        window.onbeforeunload =   function()
                        { SaveState();}

            var swfVersionStr = "10.0.0";
            var xiSwfUrlStr = "playerProductInstall.swf";
            var flashvars = {Swffile:"flash/2012/3q/Depletion_of_radio-resistant_regulatory_T_cells/{Depletion_of_radio-resistant_regulatory_T_cells[*,0].swf,39}"};
            var params = {};
            params.quality = "high";
            params.bgcolor = "#869ca7";
            params.allowscriptaccess = "sameDomain";
            params.allowfullscreen = "true";
            var attributes = {};
            attributes.id = "flowcytoView";
            attributes.name = "flowcytoView";
            attributes.align = "middle";
            swfobject.embedSWF(
                "flash/flowcytoview/flowcytoView.swf", "flashContent",
                "750", "600",
                swfVersionStr, xiSwfUrlStr,
                flashvars, params, attributes);
            swfobject.createCSS("#flashContent", "display:block;text-align:left;");
</script>

<object type="application/x-shockwave-flash" id="flowcytoView" name="flowcytoView" align="middle" data="flash/flowcytoview/flowcytoView.swf" width="750" height="600"><param name="quality" value="high"><param name="bgcolor" value="#869ca7"><param name="allowscriptaccess" value="sameDomain"><param name="allowfullscreen" value="true"><param name="flashvars" value="Swffile=flash/2012/3q/Depletion_of_radio-resistant_regulatory_T_cells/{Depletion_of_radio-resistant_regulatory_T_cells[*,0].swf,39}"></object>

huzengwu

niwanmao 发表于 2012-7-20 10:15

                               
登录/注册后可看大图

huzengwu 发表于 2012-7-19 21:06
http://www.ncbi.nlm.nih.gov/pubmed/22806892网址
能弄到全文就好了

谢谢老师