靶向树突细胞（T-DC）相关

flyer625

各位老师好，最近看到江苏安泰公司提及靶向树突细胞（T-DC）可以治疗肿瘤，想问一下，T-DC和CIK是一回事吗？这种细胞可以用流式检测吗？

mengdecao

应该不是一回事。
Cytokine-induced killer cells (CIK) are existing cells in human’s body, its responsibility is to search and kill the cancer cells. They are CD3-and CD56-positive, non-major histocompatibility complex (MHC)-restricted, natural killer (NK)-like T lymphocytes, generated ex-vivo by incubation of peripheral blood lymphocytes (PBLs) with anti-CD3 monoclonal antibody, interleukin (IL)-2, IL-1, and interferon gamma (IFN-gamma) and then expanded. When reintroduced back to patients after autologous stem cell transplantation, CIK cells may recognize and kill tumor cells associated with minimal residual disease (MRD). CIK cells may have enhanced cytotoxic activity compared to lymphokine-activated killer (LAK) cells.

The goal of DC-based cancer immunotherapy is to use the cells(DC) to prime specific antitumor immunity through the generation of effector cells(such as T cells) that attack and lyse tumors.

用流式方法检测这些细胞应该是可行的。

niwanmao

CIK用的是细胞因子诱导NK细胞分化为有效杀伤的NK细胞，而DC则是经过抗原诱导，形成能够有效递呈抗原的APC。简言之，CIK是直接杀伤的，T-DC则只是起到递呈肿瘤抗原作用，没有直接杀伤肿瘤细胞作用。

flyer625

这个应该检测什么指标呢

niwanmao

flyer625 发表于 2015-5-15 19:10
这个应该检测什么指标呢

测DC指标，站内可以搜索

flyer625

谢谢老师。