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发表于 2012-5-28 09:45:36
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liuxin 发表于 2012-5-26 21:26
我做了不破膜的，可以。
查了下资料：
CD206是个跨膜的分子，所有破了膜之后，可结合的位点暴露得更完全，使其结合能力增高
The mannose receptor (MR), also known as macrophage MR or CD206, is a 162-175 kD type I membrane protein. It contains an N-terminal, cystein-rich domain, and eight C-type lectin-like
domains (CTLDs), beside a transmembrane and a cytoplasmic domain. CD206 is expressed by macrophages, dendritic cells, and subsets of endothelial cells, but not on monocytes. The MR
recognizes multiple mainly microbial carbohydrates with mannose, fucose, or N-acetyl glucosamine residues. The MR mediates endocytosis and phagocytosis, linked to antigen presentation. It
plays an important role in host defense and provides a link between innate and adaptive immunity.
Feinberg, H. et al. (2000) Structure of a C-type carbohydrate recognition
domain from the macrophage mannose receptor. J. Biol. Chem. 275: 21539–
21548. |
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发表于 2012-5-25 06:52:24
