辅助性T细胞的Th1/Th2模型

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引用自：http://en.wikipedia.org/wiki/T_helper_cell


辅助性T细胞的Th1/Th2模型

Th1/Th2模型

下表列举了Th1和Th2的一些区别：

	Type 1/ Th1	Type 2/ Th2
效应细胞	Macrophage	B-cell
产生的细胞因子	interferon-γ and TGF-beta. (Interleukin-2 was classically associated with Th1 cells, but this association may be misleading; IL-2 is produced by all helper T cells early in their activation.) interleukin-10production has been shown to be induced in activated Th1 cell[2]	interleukin-4, interleukin-5, interleukin-6, interleukin-10, interleukin-13
介导的免疫系统	Cellular immune system. Maximizes the killing efficacy of the macrophages and the proliferation of cytotoxic CD8+ T cells. Also promotes the production of opsonizing antibodies	Humoral immune system. Stimulates B-cells into proliferation, to induce B-cell antibody class switching, and to increase neutralizing antibodyproduction.
其它功能	The Type 1 cytokine IFN-γ increases the production ofinterleukin-12 by dendritic cells and macrophages, and via positive feedback, IL-12 stimulates the production ofIFN-γ in helper T cells, thereby promoting the Th1 profile. IFN-gamma also inhibits the production of cytokines such as interleukin-4, an important cytokine associated with the Type 2 response, and thus it also acts to preserve its own response.	The Type 2 response promotes its own profile using two different cytokines.Interleukin-4 acts on helper T cells to promote the production of Th2 cytokines (including itself; it is auto-regulatory), while interleukin-10(IL-10) inhibits a variety of cytokines including interleukin-2 and IFN-γin helper T cells and IL-12 in dendritic cells and macrophages. The combined action of these two cytokines suggests that once the T cell has decided to produce these cytokines, that decision is preserved (and also encourages other T cells to do the same).

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