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NK细胞大量存在于母胎界面，但其作用仍然未知。本研究显示了在同种异体自然怀孕中，Th17和局部炎症反应可发生在母胎界面，蜕膜内的NK细胞中CD56(bright)CD27(+) NK亚群通过 IFN-γ 抑制Th17细胞而促进免疫耐受及后续顺利的怀孕。而在习惯性自发流产患者中，NK细胞失去了该调节反应。该文影响因子9.68分。
Proc Natl Acad Sci U S A. 2012 Dec 27. [Epub ahead of print]
Natural killer cells promote immune tolerance by regulating inflammatory TH17 cells at the human maternal-fetal interface.
Fu B , Li X , Sun R , Tong X , Ling B , Tian Z , Wei H .
Source
Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, University of Science and Technology of China, Anhui 230027, China.
Abstract
Natural killer (NK) cells accumulate at the maternal-fetal interface in large numbers, but their exact roles in successful pregnancy remain poorly defined. Here, we provide evidence that T(H)17 cells and local inflammation can occur at the maternal-fetal interface during natural allogenic pregnancies. We found that decidual NK cells promote immune tolerance and successful pregnancy by dampening inflammatory T(H)17 cells via IFN-γ secreted by the CD56(bright)CD27(+) NK subset. This NK-cell-mediated regulatory response is lost in patients who experience recurrent spontaneous abortions, which results in a prominent T(H)17 response and extensive local inflammation. This local inflammatory response further affects the regulatory function of NK cells, leading to the eventual loss of maternal-fetal tolerance. Thus, our data identify NK cells as key regulatory cells at the maternal-fetal interface by suppressing T(H)17-mediated local inflammation.
PMID: 23271808 [PubMed - as supplied by publisher]
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发表于 2013-1-1 21:15:34
发表于 2013-1-15 11:13:02
