CMV携带者脑脊液中效应记忆T和末期记忆T并不升高

niwanmao

CMV（巨细胞病毒）携带者外周血中的效应记忆T和末期记忆T淋巴细胞较正常人显著升高。
脑脊液中由于存在中央记忆T细胞，故认为中枢神经系统具有免疫监视作用，作者为此研究CMV携带者的脑脊液中效应记忆T和末期记忆T是否也增高。但结果证明，CMV携带者和正常人的脑脊液中效应记忆T和末期记忆T比例均非常低，两者之间没有统计学差异。
－－－详见原文，请有权限的朋友自行下载－－－
Cytometry B Clin Cytom. 2013 Feb 7. doi: 10.1002/cyto.b.21073. [Epub ahead of print]
Effector memory and late memory T cells accumulate in the blood of CMV-carrying individuals but not in their cerebrospinal fluid.
de Jongste AH   , de Graaf MT   , van den Broek PD   , Kraan J   , Sillevis Smitt PA   , Gratama JW   .
Source
Department of Medical Oncology, Erasmus University Medical Centre/Daniel Den Hoed Cancer Centre, Groene Hilledijk 301, 3075EA, Rotterdam, The Netherlands; Department of Neurology, Erasmus University Medical Centre, 's-Gravendijkwal 230, 3015CE, Rotterdam, The Netherlands.

Abstract
Cytomegalovirus (CMV)-carrying individuals have significantly higher levels of effector memory and late memory T lymphocytes in their blood than non-carriers. To date, it is well recognized that the central nervous system is subjected to active immunosurveillance, as evidenced by the presence of central memory T cells in cerebrospinal fluid (CSF) of healthy individuals. In order to investigate whether levels of effector memory and late memory T cells were also increased in the CSF of CMV-carrying individuals, we characterized CD4(+) and CD8(+) T-cell subsets in CSF and blood of both groups. Effector memory and late memory T cells were only rarely seen in CSF, which was similar in CMV carriers and non-carriers. In conclusion, there was no demonstrable difference in the numbers of CSF effector memory and late memory T cells between CMV seronegative and CMV seropositive individuals. © 2013 International Clinical Cytometry Society.
PMID: 23401348
全文链接：http://onlinelibrary.wiley.com/doi/10.1002/cyto.b.21073/pdf