| CD名称 |
表达该抗原的常见细胞 |
分子量 |
功能 |
别名 |
相关CD分子 |
| CD1a,b,c,d |
皮层胸腺细胞，郎罕氏细胞，树突状细胞，B细胞(CD1c),小肠上皮细胞，平滑肌细胞，血管(CD1d) |
43-49 |
类似MHC I类分子，与b2-微球蛋白有关，可能在脂质抗原的递呈上有着特殊作用。 |
|
Ig superfamily (IgSF) |
| CD2 |
T细胞,胸腺细胞, NK细胞 |
45-58 |
粘附分子，连接CD58 (LFA-3).连接胞内的Lck并活化T细胞 |
T11, LFA-2 |
IgSF |
| CD2R |
活化的T细胞 |
45-58 |
activation-dependent conformational form of CD2 |
T11-3 |
IgSF |
| CD3 |
Thymocytes, T cells |
Multiple chains。Gamma:25-28；delta:20；epsilon:20；zeta:16；nu:22 |
Associated with the T cell antigen receptor. Required for cell surface expression of and signal transduction by TCR. Cytoplasmic domains contain ITAM motifs and bind cytoplasmic tyrosine kinases. |
T3 |
IgSF (gde)；z/h related to FcR g chain |
| CD4 |
Thymocyte subsets, helper and inflammatory T cells (about two thirds of peripheral T cells), monocytes, macrophages |
55 |
Coreceptor for MHC class II molecules. Binds Lck on cytoplasmic face of membrane. Receptor for HIV-I and HIV-2 gp120.
MHC II类分子的协同受体 |
T4, L3T4 |
IgSF |
| CD5 |
Thymocytes, T cells, subset of B cells |
67 |
Binds to CD72 |
T1, Ly1 |
Scavenger receptor |
| CD6 |
Thymocytes, T cells, B cell CLL |
100-130 |
unknown. |
T12 |
Scavenger receptor |
| CD7 |
Pluripotential hematopoietic cells, thymocytes, T cells |
40 |
unknown, cytoplasmic domain binds PI-3 kinase on crosslinking. Marker for T cell ALL and pluripotential stem cell leukemias |
|
IgSF |
| CD8 |
Thymocyte subsets, cytotoxic T cells (about one third of peripheral T cells) |
a: 32-34 b: 32-34 |
Coreceptor for MHC class I molecules. Binds lck on cytoplasmic face of membrane |
T8, Lyt2,3 |
IgSF |
| CD9 |
Pre-B cells, monocytes, eosinophils, basophils, platelets, activated T cells, brain and peripheral nerves, vascular smooth muscle |
24 |
mediates platelet aggregation and activation via FcgRIIa, may play a role in cell migration |
|
Transmembrane 4 superfamily |
| CD10 |
B and T cell precursors, bone marrow stromal cells |
100 |
zinc metalloproteinase, marker for pre B ALL |
Neutral endopeptidase, Common Acute Lymphocytic Leukemia Antigen (CALLA) |
|
| CD11a |
lymphocytes, granulocytes, monocytes and macrophages |
180 |
aL subunit of integrin LFA-1 (associated with CD18) ; binds to CD54 (ICAM-1), ICAM-2 and ICAM-3 |
LFA-1 |
integrin a |
| CD11b |
myeloid and natural killer cells |
170 |
aM subunit of integrin CR3 (associated with CD18) ; binds CD54, complement component iC3b and extracellular matrix proteins |
Mac-1 |
integrin a |
| CD11c |
myeloid cells |
150 |
aX subunit of integrin CR4 (associated with CD18) ; binds fibrinogen |
CR4, p150, 95 |
integrin a |
| CDw12 |
monocytes, granulocytes, platelets |
90-120 |
unknown |
|
|
| CD13 |
myelomonocytic cells |
150-170 |
zinc metalloproteinase |
aminopeptidase N |
|
| CD14 |
myelomonocytic cells |
53-55 |
receptor for complex of LPS and LPS binding protein (LBP) |
|
|
| CD15 |
neutrophils, eosinophils, monocytes |
|
branched pentasaccharide, expressed on glycolipids and many cell surface glycoproteins; the sialylated form is a ligand for CD62E (ELAM) |
Lewsi-x (Lex) |
|
| CD16a |
neutrophils, NK cells, macrophages |
two forms, one PI-linked, one with transmembrane anchor peptide 50-80 |
component of low affinity Fc receptor, FcgRIII, mediates phagocytosis, cytokine production and ADCC. |
FcgRIII |
IgSF |
| CDw17 |
neutrophils, monocytes, platelets |
|
lactosyl ceramide, a cell surface glycosphingolipid |
|
|
| CD18 |
Leukocytes |
95 |
integrin b2 subunit, associates with CD11a,b and c. |
|
integrin b |
| CD19 |
B cells, follicular dendritic cells |
95 |
forms complex with CD21 (CR2)and CD81 (TAPA-1); coreceptor for B cells - cytoplasmic domain binds cytoplasmic tyrosine kinases and PI-3 kinase. |
|
IgSF |
| CD20 |
B cells |
33-37 |
Oligomers of CD20 may form a Ca2+ channel; possible role in regulating B cell activation |
|
Transmembrane 4 superfamily |
| CD21 |
mature B cells, FDC |
145 |
receptor for complement component C3d, EBV. With CD19 and CD81 forms coreceptor for B cells |
CR2 |
complement control protein (CCP) superfamily |
| CD22 |
mature B cells |
a: 130；b: 140 |
Adhesion of B cells to monocytes, T cells |
BL-CAM |
IgSF |
| CD23 |
mature B cells, activated macrophages, eosinophils, follicular dendritic cells, platelets |
45 |
low affinity receptor for IgE, regulates IgE synthesis; ligand for CD19:CD21:CD81 coreceptor |
FceRII |
C-type lectin |
| CD24 |
B cells, granulocytes |
35-45 |
unknown |
possible human homologue of mouse Heat Stable Antigen (HSA) or J11d. |
|
| CD25 |
activated T cells, B cells, monocytes |
a:55；b:75 |
IL-2 receptor |
Tac |
a:CCP；b: cytokine receptor superfamily |
| CD26 |
Activated B and T cells, macrophages |
110 |
Exopeptidase, cleaves N terminal X-Pro or X-Ala dipeptides from polypeptides. |
Dipeptidyl peptidase IV |
type II transmembrane glycoprotein |
| CD27 |
Medullary thymocytes, T cells, NK cells and some B cells |
55 |
binds CD70; can function as a costimulator for T and B cells |
|
TNF receptor superfamily |
| CD28 |
T cell subsets, activated B cells |
44 |
Activation of naive T cells, receptor for costimulatory signal (signal 2) binds CD80 (B7-1) and B7-2 |
Tp44 |
IgSF |
| CD29 |
Leukocytes |
130 |
Integrin b1 subunit, associates with CD49a in VLA-1 integrin |
|
|
| CD30 |
Activated T, B and NK cells, monocytes |
120 |
Binds CD30L; crosslinking CD30 enhances proliferation of B and T cells |
Ki-1 |
TNF receptor superfamily |
| CD31 |
monocytes, platelets, granulocytes, T cell subsets, endothelial cells |
130-140 |
Adhesion molecule, mediating both leukocyte/endothelial and endothelial/endothelial interactions |
PECAM-1 |
IgSF |
| CDw32 |
Monocytes, granulocytes, B cells eosinophils |
40 |
low affinity Fc receptor for aggregated Ig/immune complexes |
FcgRII |
IgSF |
| CD33 |
myeloid progenitor cells, monocytes |
67 |
unknown |
|
IgSF |
| CD34 |
hematopoietic precursors, capillary endothelium |
105-120 |
Ligand for CD62 (L-selectin) |
|
|
| CD35 |
Erythrocytes, B cells, monocytes, neutrophils, eosinophils, FDC |
250 |
Complement receptor 1, binds C3B and C4b, mediates phagocytosis |
CR1 |
CCP superfamily |
| CD36 |
platelets, monocytes, endothelial cells |
88 |
platelet adhesion molecule; involved in recognition and phagocytosis of apoptosed cells |
platelet GPIV, GPIIIb |
|
| CD37 |
mature B cells, mature T cells, myeloid cells |
40-52 |
unknown, may be involved in signal transduction; forms complexes with CD53, CD81, CD82 and MHC class II. |
|
Transmembrane 4 superfamily |
| CD38 |
early B and T cells, activated T cells, germinal centre B cells, plasma cells |
45 |
NAD glycohydrolase, augments B cell proliferation |
T10 |
|
| CD39 |
activated B cells, activated NK cells, macrophages, dendritic cells |
78 |
unknown, may mediate adhesion of B cells |
|
|
| CD40 |
B cells, macrophages, dendritic cells, basal epithelial cells |
48 |
binds CD40L ; receptor for costimulatory signal for B cells, promotes growth, differentiation and isotype switching of B cells, cytokine production by macrophages and dendritic cells |
|
NGF receptor superfamily |
| CD41 |
platelets, megakaryocytes |
dimer:GPIIba: 125；GPIIbb: 22 |
aIIb integrin, associates with CD61 to form GPIIb, binds fibrinogen, fibronectin, von Willebrand factor and thrombospondin |
GPIIb |
integrin a |
| CD42a,b,c,d |
platelets, megakaryocytes |
complex of four polypeptides。A: 22；b: 135, 23；C: 22；d: 85 |
binds von Willebrand factor, thrombin; essential for platelet adhesion at sites of injury |
a: GPIX；b: GPIba；C: GPIbb；d: GPV |
Leucine rich repeat |
| CD43 |
leukocytes, except resting B cells |
115-135 (neutrophils)；95-115 (T cells) |
binds CD54 (ICAM-1) has extended structure, approx 45nm long and may be anti-adhesive |
leukosialin, sialophorin |
mucin |
| CD44 |
leukocytes, erythrocytes |
80-95 |
binds hyaluronic acid, mediates adhesion of leukocytes |
Hermes antigen, Pgp-1 |
Link |
| CD45 |
all hematopoietic cells |
180-240 (multiple isoforms) |
tyrosine phosphatase, augments signalling through antigen receptor of B and T cells, multiple isoforms result from alternative splicing (see below) |
Leukocyte common antigen (LCA), T200, B220 |
Fibronectin type III |
| CD45RO |
T cell subsets, B cell subsets, monocytes, macrophages |
180 |
isoform of CD45 containing none of the A, B and C exons |
|
Fibronectin type III |
| CD45RA |
B cells, T cell subsets (naive T cells) monocytes |
205-220 |
isoforms of CD45 containing the A exon |
|
Fibronectin type III |
| CD45RB |
T cell subsets, B cells, monocytes, macrophages, granulocytes |
190-220 |
isoforms of CD45 containing the B exon |
T200 |
Fibronectin type III |
| CD46 |
hematopoietic and non-hematopoietic nucleated cells |
56/66 (splice variants) |
membrane cofactor protein, binds to C3b and C4b to permit their degradation by Factor I |
MCP |
CCP superfamily |
| CD47 |
all cells |
47-52 |
unknown, associated with Rh blood group |
|
|
| CD48 |
leukocytes |
40-47 |
unknown |
Blast-1 |
IgSF |
| CD49a |
activated T cells, monocytes, neuronal cells, smooth muscle |
200 |
a1 integrin, associates with CD29, binds collagen, laminin-1 |
VLA-1 |
integrin a |
| CD49b |
B cells, monocyte, platelets, megakaryocytes, neuronal, epithelial and endothelial cells, osteoclasts |
160 |
a2 integrin, associates with CD29, binds collagen, laminin |
VLA-2, platelet GPIa |
integrin a |
| CD49c |
B cells, many adherent cells |
125,30dimer |
a3 integrin, associates with CD29, bindslaminin-5, fibronectin, collagen, entactin, invasin |
VLA-3 |
integrin a |
| CD49d |
Broad distribution includes B cells, thymocytes, monocytes, granulocytes, dendritic cells |
150 |
a4 integrin, associates with CD29, binds fibronectin, MadCAM-1, VCAM-1 |
VLA-4 |
integrin a |
| CD49e |
Broad distribution includes memory T cells, monocytes, platelets |
135, 25 dimer |
a5 integrin, associates with CD29, binds fibronectin, invasin |
VLA-5 |
integrin a |
| CD49f |
T lymphocytes, monocytes, platelets, megakaryocyes, trophoblast |
125, 25 dimer |
a6integrin, associates with CD29, binds laminins, invasin, merosin |
VLA-6 |
integrin a |
| CD50 |
thymocytes, T cells, B cells,monocytes, granulocytes |
130 |
Binds integrin CD11a/CD18 |
ICAM-3 |
IgSF |
| CD51 |
platelets, megakaryocytes |
125,24 dimer |
av integrin, associates with CD61, binds vitronectin, von Willebrand factor, fibrinogen and thrombospondin; may be receptor for apoptotic cells |
vitronectin receptor |
integrin a |
| CD52 |
thymocytes, T cells, B cells (not plasma cells), monocytes, granulocytes, spermatozoa |
apparent MW is 25-29 by SDS gel electrophoresis; true MW is 8-9 |
unknown, target for antibodies used therapeutically to deplete T cells from bone marrow |
CAMPATH-1 HE5 |
|
| CD53 |
leukocytes |
35-42 |
unknown |
MRC OX44 |
Transmembrane 4 superfamily |
| CD54 |
hematopoietic and non-hematopoietic cells |
75-115 |
InterCellular Adhesion Molecule, (ICAM)-1 binds CD11a/CD18 (LFA-1) and CD11b/CD18 (Mac-1) integrins, receptor for rhinovirus |
ICAM-1 |
IgSF |
| CD55 |
hematopoietic and non-hematopoietic cells |
60-70 |
Decay Accelerating Factor (DAF), binds C3b, disassembles C3/C5 convertase |
DAF |
CCP superfamily |
| CD56 |
NK cells |
135-220 |
isoform of Neural Cell Adhesion Molecule (NCAM), adhesion molecule |
NKH-1 |
IgSF |
| CD57 |
NK cells subsets of T cells, B cells and monocytes |
|
oligosaccharide, found on many cell surface glycoproteins |
HNK-1, Leu-7 |
|
| CD58 |
hematopoietic and non-hematopoietic cells |
55-70 |
Leukocyte Function-associated Antigen-3 (LFA-3), binds CD2, adhesion molecule |
LFA-3 |
IgSF |
| CD59 |
hematopoietic and non-hematopoietic cells |
19 |
binds comlement components C8 and C9, blocks assembly of membrane attack complex |
Protectin, Mac inhibitor |
|
| CDw60 |
T cell subsets, platelets, monocytes |
|
9-O-acetylated disialoyl group present on gangliosides, predominantly ganglioside D3 |
|
|
| CD61 |
platelets, megakaryocytes, macrophages |
110 |
integrin b3 subunit, associates with CD41 (GPIIb/IIIa) or CD51 (vitronectin receptor) |
|
integrin b |
| CD62E |
endothelium |
140 |
endothelium leukocyte adhesion molecule (ELAM), bindssialyl-Lewis x, mediates rolling interaction of neutrophils on endothelium |
ELAM-1, E-selectin |
C type lectin, EGF and CCP superfamily |
| CD62L |
B cells, T cells, monocytes, NK cells |
150 |
leukocyte adhesion molecule (LAM), binds CD34, GlyCAM, mediates rolling interactions with endothelium |
LAM-1, L-selectin, LECAM-1 |
C type lectin EGF and CCP superfamily |
| CD62P |
platelets, megakaryocytes, endothelium |
140 |
adhesion molecule, binds PSGL-1, mediates interaction of platelets with endothelial cells, monocytes and rolling interaction of leukocytes on endothelium |
P-selectin, PADGEM |
C type lectin EGF and CCP superfamily |
| CD63 |
activated platelets, monocytes, macrophages |
53 |
unknown, is lysosomal membrane protein translocated to cell surface after activation |
platelet activation antigen |
Transmembrane 4 superfamily |
| CD64 |
monocytes, macrophages |
72 |
high affinity receptor for IgG, binds IgG3>IgG1>IgG4>>>IgG2, mediates phagocytosis, antigen capture, ADCC |
FcgRI |
IgSF |
| CD65 |
myeloid cells |
|
oligosaccharide component of a ceramide dodecasaccharide |
|
|
| CD66a |
neutrophils |
160-180 |
unknown, member of carcinoembryonic antigen (CEA) family (see below) |
biliary glycoprotein-1 (BGP-1) |
IgSF |
| CD66b |
granulocytes |
95-100 |
unknown, member of carcinoembryonic antigen (CEA) family |
previously CD67 |
IgSF |
| CD66c |
neutrophils, colon carcinoma |
90 |
unknown, member of carcinoembryonic antigen (CEA) family |
Nonspecific Crossreacting Antigen (NCA) |
IgSF |
| CD66d |
neutrophils |
30 |
unknown, member of carcinoembryonic antigen (CEA) family |
|
IgSF |
| CD66e，CD66f |
adult colon epithelium, colon carcinoma |
180-200 |
unknown, member of carcinoembryonic antigen (CEA) family |
CarcinoEmbryonic Antigen (CEA) |
IgSF |
| CD68 |
monocytes, macrophages, neutrophils, basophils, large lymphocytes |
110 |
unknown |
macrosialin |
|
| CD69 |
activated B cells, activated T cells, activated macrophages, activated NK cells |
28, 32 homodimer |
unknown, early activation antigen |
Activation Inducer Molecule (AIM) |
C-type lectin |
| CD70 |
activated B cells, activated T cells, macrophages |
75,95,170 |
Ligand for CD27, may function in co-stimulation of B and T cells |
Ki-24 |
TNF-like |
| CD71 |
All proliferating cells, hence activated leukocytes |
95 homodimer |
transferrin receptor |
T9 |
|
| CD72 |
B cells (not plasma cells) |
42 homodimer |
unknown, ligand for CD5 |
Lyb-2 |
C type lectin |
| CD73 |
B cell subsets, T cell subsets |
69 |
ecto-5?-nucleotidase, dephosphorylates nucleotides to allow nucleoside uptake |
|
|
| CD74 |
B cells, macrophages, monocytes, MHC class II positive cells |
33,35,41,43 (alternate initiation and splicing) |
MHC class II associated Invariant chain |
Ii, Ig |
|
| CD75 |
mature B cells, T cell subsets |
|
sialoglycan moiety, ligand for CD22, mediates B cell/B cell adhesion |
|
|
| CD76 |
mature B cells, T cell subsets |
|
a 2,6 sialylated polylactosamine expressed on glycosphingolilpids and glycoproteins |
|
|
| CD77 |
germinal center B cells |
|
Neutral glycosphingolipid (Gala1?4Galb1?4Glcb1?ceramide), binds Shiga toxin, Crosslinking induces apoptosis |
Globotriaocylceramide (Gb3), Pk blood group |
|
| Cdw78 |
B cells |
|
unknown |
Ba |
|
| CD79a,b |
B cells |
a: 40-45 b: 37 |
components of B cell antigen receptor analogous to CD3, required for cell surface expression and signal transduction |
Iga, Igb |
IgSF |
| CD80 |
B cell subset |
60 |
costimulator, ligand for CD28 and CTLA-4 |
B7 (now B7-1), BB1 |
IgSF |
| CD81 |
lymphocytes |
26 |
associates with CD19, CD21 to form B cell coreceptor |
Target of AntiProliferative Antibody (TAPA-1) |
Transmembrane 4 superfamily |
| CD82 |
leukocytes |
50-53 |
unknown |
R2 |
Transmembrane 4 superfamily |
| CD83 |
Activated B cells, activated T cells, circulating dendritic cells (veil cells) |
43 |
|
HB15 |
IgSF |
| CDw84 |
monocytes, platelets, circulating B cells |
73 |
|
GR6 |
|
| CD85 |
monocytes, circulating B cells |
120, 83 |
|
GR4 |
|
| CD86 |
monocytes, activated B cells, dendritic cells |
80 |
Ligand for CD28 and CTLA4 |
B7.2 |
IgSF |
| CD87 |
granulocytes, monocytes, macrophages, T cells, NK cells, wide variety of nonhematopioetic cell types |
35-59 |
Receptor for urokinase plasminogen activator |
uPAR |
Ly-6 superfamily |
| CD88 |
polymorphonuclear leukocytes, macrophages, mast cells |
43 |
Receptor for complement component C5a |
C5aR |
G protein complement receptor |
| CD89 |
monocytes, macrophages, granulocytes, neutrophils, B cell subsets, T cell subsets |
50-70 |
IgA receptor |
FcaR |
IgSF |
| CD90 |
CD34+ prothymocytes (human) thymocytes, T cells (mouse) |
18 |
unknown |
Thy-1 |
IgSF |
| CD91 |
monocytes, many nonhematopoietic cells |
515, 85 dimer |
a2 macroglobulin receptor |
|
EGF, LDL receptor superfamily |
| CDw92 |
neutrophils, monocytes, platelets, endothelium |
70 |
|
GR9 |
|
| CD93 |
neutrophils, monocytes, endothelium |
120 |
|
GR11 |
|
| CD94 |
T cell subsets, NK cells |
43 |
|
KP43 |
|
| CD95 |
wide variety of cell lines in vivodistribution uncertain |
43 |
binds TNF-like ligand, induces apoptosis |
Apo-1, Fas |
NGF receptor superfamily |
| CD96 |
activated T cells, NK cells |
160 |
|
T cell ACTivation Increased Late Expression (TACTILE) |
IgSF |
| CD97 |
activated B and T cells, monocytes, granulocytes |
75-85 |
Binds CD55 |
GR1 |
EGF, G protein complement receptor |
| CD98 |
T cells, B cells, NK cells, granulocytes, all human cell lines |
80, 45 heterodimer |
may be amino acid transporter |
4F2, FRP-1 |
|
| CD99 |
Peripheral blood lymphocytes, thymocytes |
32 |
unknown |
MIC2, E2 |
|
| CD100 |
Hematopoietic cells |
150 homodimer |
unknown |
GR3 |
|
| CD101 |
monocytes, granulocytes, dendritic cells, activated T cells |
120 homodimer |
unknown |
V7, BPC#4 |
IgSF |
| CD102 |
Resting lymphocytes, monocytes, vascular endothelial cells (strongest) |
55-65 |
binds CD11a/CD18 (LFA-1) but not CD11b/CD18 (Mac-1) |
ICAM-2 |
IgSF |
| CD103 |
Intraepithelial lymphocytes, 2-6% of peripheral blood lymphocytes |
150,25 |
aE integrin |
HML-1, a6,aE integrin |
integrin a |
| CD104 |
CD4-CD8- thymocytes, neuronal, epithelial and some endothelial cells, Schwann cells, trophoblasts |
220 |
integrin b4, associates with CD49f, binds laminins |
b4 integrin |
integrin b |
| CD105 |
Endothelial cells, activated monocytes and macrophages, bone marrow cell subsets |
90 homodimer |
Binds TGFb |
Endoglin |
|
| CD106 |
Endothelial cells |
100,110 |
Adhesion Molecule, ligand for VLA-4 |
VCAM-1 |
IgSF |
| CD107a |
Activated platelets, activated T cells, activated neutrophils, activated endothelium |
110 |
Unknown, is lysosomal protein translocated to the cell surface after activation |
Lysosomal Associated Membrane Protein-1 (LAMP-1) |
|
| CD107b |
Activated platelets, activated T cells, activated neutrophils, activated endothelium |
120 |
Unknown, is lysosomal protein translocated to the cell surface after activation |
LAMP-2 |
|
| CDw108 |
Erythrocytes, circulating lymphocytes, lymphoblasts |
80 |
unknown |
GR2, John-Milton-Hagen blood group antigen |
|
| CD109 |
Activated T cells, activated platelets, vascular endothelium |
170 |
unknown |
Platelet activation factor, GR56 |
|
| CD110-113 |
not yet assigned |
|
|
|
|
| CD114 |
Granulocytes, monocytes |
95,139 |
Granulocyte colony stimulating factor (G-CSF) receptor |
G-CSFR |
|
| CD115 |
monocytes, macrophages |
150 |
Macrophage Colony Stimulating Factor (M-CSF) receptor |
M-CSFR, c-fms |
IgSF, tyrosine kinase |
| CD116 |
monocytes, neutrophils,eosinophils, endothelium |
70-85 |
Granulocyte, Macrophage Colony Stimulating Factor (GM-CSF) receptor a chain |
GM-CSFRa |
cytokine receptor superfamily, fibronectin type III superfamily |
| CD117 |
hematopoietic progenitors |
145 |
Stem Cell Factor (SCF) receptor |
c-kit |
IgSF tyrosine kinase |
| CD118 |
Broadly expressed |
|
Interferon a, b receptor |
IFNa,bR |
|
| CD119 |
marophages, monocytes, B cells, endothelium |
90-100 |
Interferon g receptor |
IFNgR |
|
| CD120a |
hematopoietic and non-hematopoietic cells, highest on epithelial cells |
50-60 |
TNF receptor, binds both TNFa and TNFb |
TNFR-I |
TNF receptor superfamily |
| CD120b |
hematopoietic and non-hematopoietic cells, highest on myeloid cells |
75-85 |
TNF receptor, binds both TNFa and TNFb |
TNFR-II |
TNF receptor superfamily |
| CD121a |
thymocytes ,T cells |
80 |
type I interleukin 1 receptor, binds IL-1a and IL-1b |
IL-1R type I |
IgSF |
| CDw121b |
B cells, macrophages, monocytes |
60-70 |
type II interleukin 1 receptor, binds IL-1a and IL-1b |
IL-1R, ytpe II |
IgSF |
| CD122 |
Natural Killer cells, resting T cell subsets, some B cell lines |
75 |
IL-2 receptor b chain |
IL-2Rb |
cytokine receptor superfamily；fibronectin type III superfamily |
| CD123 |
Bone marrow stem cells, granulocytes, monocytes, megakaryocytes |
70 |
IL-3 receptor a chain |
IL-3R |
cytokine receptor superfamily；fibronectin type III superfamily |
| CD124 |
Mature B and T cells, hematopoietic precursor cells |
130-150 |
IL-4 receptor |
IL-4R |
cytokine receptor superfamily；fibronectin type III superfamily |
| CD125 |
Eosinophils, basophils, activated B cells |
55-60 |
IL-5 receptor |
IL-5R |
cytokine receptor superfamily；fibronectin type III superfamily |
| CD126 |
Activated B cells and plasma cells, weak on most other leukocytes |
80 |
IL-6 receptor a subunit |
IL-6R |
IgSF Cytokine receptor superfamily；fibronectin type III superfamily |
| CD127 |
Bone marrow lymphoid precursors, pro-B cells, mature T cells, monocytes |
68-79, possibly forms homodimers |
IL-7 receptor |
IL-7R |
fibronectin type III superfamily |
| CDw128 |
Neutrophils, basophils, T cell subsets |
58-67 |
IL-8 receptor |
IL-8R |
G protein coupled receptor superfamily |
| CD129 |
Not yet assigned |
|
|
|
|
| CD130 |
Most cell types, strong on activated B cells and plasma cells |
130 |
common subunit of IL-6, IL-11, oncostatin-M (OSM), and leukemia inhibitory factor (LIF) receptors |
IL-6Rb, IL-11Rb, OSMRb, LIFRb |
IgSF；Cytokine receptor superfamily；fibronectin type III superfamily |
| CDw131 |
Myeloid progenitors, granulocytes |
140 |
common b subunit of IL-3, IL-5 and GM-CSF receptors |
IL-3Rb, IL-5Rb, GM-CSFRb |
cytokine receptor superfamily；fibronectin type III superfamily |
| CD132 |
B cells, T cells, NK cells, mast cells and neutrophils |
64 |
IL-2 receptor g chain, common subunit of IL-2, IL-4, IL-7, IL-9, IL-15 receptors |
|
cytokine receptor superfamily |
| CD134 |
activated T cells |
50 |
may act as adhesion molecule, costimulator |
OX40 |
TNF receptor superfamily |
| CD135 |
Multipotential precursors, myelomonocytic and B cell progenitors |
130,155 |
growth factor receptor |
FLK2, STK-1 |
tyrosine kinase |
| CDw136 |
Monocytes, epithelial cells, central and peripheral nervous system |
180 |
chemotaxis, phagocytosis, cell growth and differentiation |
MSP-R, RON |
tyrosine kinase |
| CDw137 |
T and B lymphocytes, monocytes, some epithelial cells |
|
costimulator of T cell proliferation |
ILA (Induced by Lymphocyte Activation), 4-1BB |
TNF receptor superfamily |
| CD138 |
B cells |
|
heparan sulphate proteoglycan, binds collagen type I |
Syndecan-1 |
|
| CD139 |
B cells |
209,228 |
unknown |
|
|
| CD140a,b |
Stromal and some endothelial cells |
Dimer。A: 180；b: 180 |
Platelet derived growth factor (PDGF) receptor alpha and beta chains |
PDGFR |
|
| CD141 |
Vascular endothelial cells, |
105 |
Anticoagulant, binds thrombin, the complex then activating protein C |
Thrombomodulin, Fetomodulin |
C-type lectin；EGF |
| CD142 |
Epidemal keratinocytes, various epithelial cells, astrocytes, Schwann cells. Absent from cells in direct contact with plasma unless induced by inflammatory mediators |
45-47 |
Major initiating factor of clotting. Binds Factor VIIa ; this complex activates Factors VII, IX and X |
Tissue Factor, thromboplastin |
fibronectin type III superfamily |
| CD143 |
Endothelial cells, except large blood vessels and kidney, epithelial cells of brush borders of kidney and small intestine, neuronal cells, activated macrophages and some T cells. Soluble form in plasma. |
170-180 |
Zn2+ metallopeptidase, dipeptidyl pedtidase, cleaves angiotensin I and bradykinin from precursor forms |
Angiotensin converting enzyme (ACE) |
|
| CD144 |
Endothelial cells |
135 |
Adhesion molecule, organises adherens junctions between endothelial cells |
VE-cadherin |
cadherin |
| CD145 |
Epithelial and some stromal cells |
25,90,110 |
Unknown |
|
|
| CD146 |
Endothelium |
130 |
potential adhesion molecule, localised at cell cell junctions |
MCAM, MUC18,S-ENDO |
IgSF |
| CD147 |
leukocytes, red blood cells, platelets, endothelial cells |
55-65 |
potential adhesion molecule |
M6, neurothelin, EMMPRIN, basigin, OX-47 |
IgSF |
| CD148 |
granulocytes, monocytes, dendritic cells, T cells, fibroblasts, nerve cells |
240-260 |
contact inhibition of cell growth |
HPTPh |
fibronectin type III superfamily；protein tyrosine phosphatase |
| CD151 |
platelets, megakaryocytes, epithelial cells, endothelial cells |
32 |
associates with b1 integrins |
PETA-3, SFA-1 |
Transmembrane 4 superfamily |
| CD152 |
Activated T cells |
33 |
Ligand for B7.1 (CD80), B7.2 (CD86); negative regulatior of T cell activation |
CTLA4 |
IgSF |
| CD153 |
Activated T cells, activated macrophages, neutrophils, B cells |
38-40 |
Ligand for CD30, may costimulate T cells |
CD30L |
TNF superfamily |
| CD154 |
Activated CD4 T cells |
28,30.,33 |
Ligand for CD40, inducer of B cell proliferation and activation |
CD40L, TRAP, T-BAM, gp39 |
TNF receptor family |
| CD155 |
Monocytes, macrophages, thymocytes, CNS neurons |
80-90 |
normal function unknown; receptor for poliovirus |
Poliovirus receptor |
IgSF |
| CD156 |
neutrophils, monocytes |
69 |
unknown, may be involved in leukocyte extravasation |
MS2, ADAM 8 (A Disintegrin and Metalloprotease) |
|
| CD157 |
Granulocytes, monocytes, bone marrow stromal cells, vascular endothelial cells, follicular dendritic cells |
42-45 (50 on monocytes) |
ADP-ribosyl cyclase, cyclic ADP-ribose hydrolase |
BST-1 |
|
| CD158a |
NK cell subsets |
50 or 58 |
Inhibits NK cell cytotoxicity on binding MHC class I molecules |
p50.1, p58.1 |
IgSF |
| CD158b |
NK cell subsets |
50 or 58 |
Inhibits NK cell cytotoxixity on binding HLA-Cw3 and related alleles |
p50.2, p58.2 |
IgSF |
| CD161 |
NK cells, T cells |
44 |
Regulates NK cytotoxicity |
NKRP1 |
C type lectin |
| CD163 |
monocytes, macrophages |
130 |
unknown |
M130 |
|
| CD166 |
Activated T cells, thymic epithelium, fibroblasts,neurons,. |
100-105 |
ligand for CD6, involved in neurite extension |
ALCAM, BEN, DM-GRASP, SC-1 |
IgSF |
发表于 2010-8-1 20:14:09
