完整的细胞表面分化抗原列表

niwanmao

标题：完整的细胞表面分化抗原列表（CD名称、别名、表达的细胞、功能等）

CD名称	表达该抗原的常见细胞	分子量	功能	别名	相关CD分子
CD1a,b,c,d	皮层胸腺细胞，郎罕氏细胞，树突状细胞，B细胞(CD1c),小肠上皮细胞，平滑肌细胞，血管(CD1d)	43-49	类似MHC I类分子，与b2-微球蛋白有关，可能在脂质抗原的递呈上有着特殊作用。		Ig superfamily (IgSF)
CD2	T细胞,胸腺细胞, NK细胞	45-58	粘附分子，连接CD58 (LFA-3).连接胞内的Lck并活化T细胞	T11, LFA-2	IgSF
CD2R	活化的T细胞	45-58	activation-dependent conformational form of CD2	T11-3	IgSF
CD3	Thymocytes, T cells	Multiple chains。Gamma:25-28；delta:20；epsilon:20；zeta:16；nu:22	Associated with the T cell antigen receptor. Required for cell surface expression of and signal transduction by TCR. Cytoplasmic domains contain ITAM motifs and bind cytoplasmic tyrosine kinases.	T3	IgSF (gde)；z/h related to FcR g chain
CD4	Thymocyte subsets, helper and inflammatory T cells (about two thirds of peripheral T cells), monocytes, macrophages	55	Coreceptor for MHC class II molecules. Binds Lck on cytoplasmic face of membrane. Receptor for HIV-I and HIV-2 gp120. MHC II类分子的协同受体	T4, L3T4	IgSF
CD5	Thymocytes, T cells, subset of B cells	67	Binds to CD72	T1, Ly1	Scavenger receptor
CD6	Thymocytes, T cells, B cell CLL	100-130	unknown.	T12	Scavenger receptor
CD7	Pluripotential hematopoietic cells, thymocytes, T cells	40	unknown, cytoplasmic domain binds PI-3 kinase on crosslinking. Marker for T cell ALL and pluripotential stem cell leukemias		IgSF
CD8	Thymocyte subsets, cytotoxic T cells (about one third of peripheral T cells)	a: 32-34 b: 32-34	Coreceptor for MHC class I molecules. Binds lck on cytoplasmic face of membrane	T8, Lyt2,3	IgSF
CD9	Pre-B cells, monocytes, eosinophils, basophils, platelets, activated T cells, brain and peripheral nerves, vascular smooth muscle	24	mediates platelet aggregation and activation via FcgRIIa, may play a role in cell migration		Transmembrane 4 superfamily
CD10	B and T cell precursors, bone marrow stromal cells	100	zinc metalloproteinase, marker for pre B ALL	Neutral endopeptidase, Common Acute Lymphocytic Leukemia Antigen (CALLA)
CD11a	lymphocytes, granulocytes, monocytes and macrophages	180	aL subunit of integrin LFA-1 (associated with CD18) ; binds to CD54 (ICAM-1), ICAM-2 and ICAM-3	LFA-1	integrin a
CD11b	myeloid and natural killer cells	170	aM subunit of integrin CR3 (associated with CD18) ; binds CD54, complement component iC3b and extracellular matrix proteins	Mac-1	integrin a
CD11c	myeloid cells	150	aX subunit of integrin CR4 (associated with CD18) ; binds fibrinogen	CR4, p150, 95	integrin a
CDw12	monocytes, granulocytes, platelets	90-120	unknown
CD13	myelomonocytic cells	150-170	zinc metalloproteinase	aminopeptidase N
CD14	myelomonocytic cells	53-55	receptor for complex of LPS and LPS binding protein (LBP)
CD15	neutrophils, eosinophils, monocytes		branched pentasaccharide, expressed on glycolipids and many cell surface glycoproteins; the sialylated form is a ligand for CD62E (ELAM)	Lewsi-x (Lex)
CD16a	neutrophils, NK cells, macrophages	two forms, one PI-linked, one with transmembrane anchor peptide 50-80	component of low affinity Fc receptor, FcgRIII, mediates phagocytosis, cytokine production and ADCC.	FcgRIII	IgSF
CDw17	neutrophils, monocytes, platelets		lactosyl ceramide, a cell surface glycosphingolipid
CD18	Leukocytes	95	integrin b2 subunit, associates with CD11a,b and c.		integrin b
CD19	B cells, follicular dendritic cells	95	forms complex with CD21 (CR2)and CD81 (TAPA-1); coreceptor for B cells - cytoplasmic domain binds cytoplasmic tyrosine kinases and PI-3 kinase.		IgSF
CD20	B cells	33-37	Oligomers of CD20 may form a Ca2+ channel; possible role in regulating B cell activation		Transmembrane 4 superfamily
CD21	mature B cells, FDC	145	receptor for complement component C3d, EBV. With CD19 and CD81 forms coreceptor for B cells	CR2	complement control protein (CCP) superfamily
CD22	mature B cells	a: 130；b: 140	Adhesion of B cells to monocytes, T cells	BL-CAM	IgSF
CD23	mature B cells, activated macrophages, eosinophils, follicular dendritic cells, platelets	45	low affinity receptor for IgE, regulates IgE synthesis; ligand for CD19:CD21:CD81 coreceptor	FceRII	C-type lectin
CD24	B cells, granulocytes	35-45	unknown	possible human homologue of mouse Heat Stable Antigen (HSA) or J11d.
CD25	activated T cells, B cells, monocytes	a:55；b:75	IL-2 receptor	Tac	a:CCP；b: cytokine receptor superfamily
CD26	Activated B and T cells, macrophages	110	Exopeptidase, cleaves N terminal X-Pro or X-Ala dipeptides from polypeptides.	Dipeptidyl peptidase IV	type II transmembrane glycoprotein
CD27	Medullary thymocytes, T cells, NK cells and some B cells	55	binds CD70; can function as a costimulator for T and B cells		TNF receptor superfamily
CD28	T cell subsets, activated B cells	44	Activation of naive T cells, receptor for costimulatory signal (signal 2) binds CD80 (B7-1) and B7-2	Tp44	IgSF
CD29	Leukocytes	130	Integrin b1 subunit, associates with CD49a in VLA-1 integrin
CD30	Activated T, B and NK cells, monocytes	120	Binds CD30L; crosslinking CD30 enhances proliferation of B and T cells	Ki-1	TNF receptor superfamily
CD31	monocytes, platelets, granulocytes, T cell subsets, endothelial cells	130-140	Adhesion molecule, mediating both leukocyte/endothelial and endothelial/endothelial interactions	PECAM-1	IgSF
CDw32	Monocytes, granulocytes, B cells eosinophils	40	low affinity Fc receptor for aggregated Ig/immune complexes	FcgRII	IgSF
CD33	myeloid progenitor cells, monocytes	67	unknown		IgSF
CD34	hematopoietic precursors, capillary endothelium	105-120	Ligand for CD62 (L-selectin)
CD35	Erythrocytes, B cells, monocytes, neutrophils, eosinophils, FDC	250	Complement receptor 1, binds C3B and C4b, mediates phagocytosis	CR1	CCP superfamily
CD36	platelets, monocytes, endothelial cells	88	platelet adhesion molecule; involved in recognition and phagocytosis of apoptosed cells	platelet GPIV, GPIIIb
CD37	mature B cells, mature T cells, myeloid cells	40-52	unknown, may be involved in signal transduction; forms complexes with CD53, CD81, CD82 and MHC class II.		Transmembrane 4 superfamily
CD38	early B and T cells, activated T cells, germinal centre B cells, plasma cells	45	NAD glycohydrolase, augments B cell proliferation	T10
CD39	activated B cells, activated NK cells, macrophages, dendritic cells	78	unknown, may mediate adhesion of B cells
CD40	B cells, macrophages, dendritic cells, basal epithelial cells	48	binds CD40L ; receptor for costimulatory signal for B cells, promotes growth, differentiation and isotype switching of B cells, cytokine production by macrophages and dendritic cells		NGF receptor superfamily
CD41	platelets, megakaryocytes	dimer:GPIIba: 125；GPIIbb: 22	aIIb integrin, associates with CD61 to form GPIIb, binds fibrinogen, fibronectin, von Willebrand factor and thrombospondin	GPIIb	integrin a
CD42a,b,c,d	platelets, megakaryocytes	complex of four polypeptides。A: 22；b: 135, 23；C: 22；d: 85	binds von Willebrand factor, thrombin; essential for platelet adhesion at sites of injury	a: GPIX；b: GPIba；C: GPIbb；d: GPV	Leucine rich repeat
CD43	leukocytes, except resting B cells	115-135 (neutrophils)；95-115 (T cells)	binds CD54 (ICAM-1) has extended structure, approx 45nm long and may be anti-adhesive	leukosialin, sialophorin	mucin
CD44	leukocytes, erythrocytes	80-95	binds hyaluronic acid, mediates adhesion of leukocytes	Hermes antigen, Pgp-1	Link
CD45	all hematopoietic cells	180-240 (multiple isoforms)	tyrosine phosphatase, augments signalling through antigen receptor of B and T cells, multiple isoforms result from alternative splicing (see below)	Leukocyte common antigen (LCA), T200, B220	Fibronectin type III
CD45RO	T cell subsets, B cell subsets, monocytes, macrophages	180	isoform of CD45 containing none of the A, B and C exons		Fibronectin type III
CD45RA	B cells, T cell subsets (naive T cells) monocytes	205-220	isoforms of CD45 containing the A exon		Fibronectin type III
CD45RB	T cell subsets, B cells, monocytes, macrophages, granulocytes	190-220	isoforms of CD45 containing the B exon	T200	Fibronectin type III
CD46	hematopoietic and non-hematopoietic nucleated cells	56/66 (splice variants)	membrane cofactor protein, binds to C3b and C4b to permit their degradation by Factor I	MCP	CCP superfamily
CD47	all cells	47-52	unknown, associated with Rh blood group
CD48	leukocytes	40-47	unknown	Blast-1	IgSF
CD49a	activated T cells, monocytes, neuronal cells, smooth muscle	200	a1 integrin, associates with CD29, binds collagen, laminin-1	VLA-1	integrin a
CD49b	B cells, monocyte, platelets, megakaryocytes, neuronal, epithelial and endothelial cells, osteoclasts	160	a2 integrin, associates with CD29, binds collagen, laminin	VLA-2, platelet GPIa	integrin a
CD49c	B cells, many adherent cells	125,30dimer	a3 integrin, associates with CD29, bindslaminin-5, fibronectin, collagen, entactin, invasin	VLA-3	integrin a
CD49d	Broad distribution includes B cells, thymocytes, monocytes, granulocytes, dendritic cells	150	a4 integrin, associates with CD29, binds fibronectin, MadCAM-1, VCAM-1	VLA-4	integrin a
CD49e	Broad distribution includes memory T cells, monocytes, platelets	135, 25 dimer	a5 integrin, associates with CD29, binds fibronectin, invasin	VLA-5	integrin a
CD49f	T lymphocytes, monocytes, platelets, megakaryocyes, trophoblast	125, 25 dimer	a6integrin, associates with CD29, binds laminins, invasin, merosin	VLA-6	integrin a
CD50	thymocytes, T cells, B cells,monocytes, granulocytes	130	Binds integrin CD11a/CD18	ICAM-3	IgSF
CD51	platelets, megakaryocytes	125,24 dimer	av integrin, associates with CD61, binds vitronectin, von Willebrand factor, fibrinogen and thrombospondin; may be receptor for apoptotic cells	vitronectin receptor	integrin a
CD52	thymocytes, T cells, B cells (not plasma cells), monocytes, granulocytes, spermatozoa	apparent MW is 25-29 by SDS gel electrophoresis; true MW is 8-9	unknown, target for antibodies used therapeutically to deplete T cells from bone marrow	CAMPATH-1 HE5
CD53	leukocytes	35-42	unknown	MRC OX44	Transmembrane 4 superfamily
CD54	hematopoietic and non-hematopoietic cells	75-115	InterCellular Adhesion Molecule, (ICAM)-1 binds CD11a/CD18 (LFA-1) and CD11b/CD18 (Mac-1) integrins, receptor for rhinovirus	ICAM-1	IgSF
CD55	hematopoietic and non-hematopoietic cells	60-70	Decay Accelerating Factor (DAF), binds C3b, disassembles C3/C5 convertase	DAF	CCP superfamily
CD56	NK cells	135-220	isoform of Neural Cell Adhesion Molecule (NCAM), adhesion molecule	NKH-1	IgSF
CD57	NK cells subsets of T cells, B cells and monocytes		oligosaccharide, found on many cell surface glycoproteins	HNK-1, Leu-7
CD58	hematopoietic and non-hematopoietic cells	55-70	Leukocyte Function-associated Antigen-3 (LFA-3), binds CD2, adhesion molecule	LFA-3	IgSF
CD59	hematopoietic and non-hematopoietic cells	19	binds comlement components C8 and C9, blocks assembly of membrane attack complex	Protectin, Mac inhibitor
CDw60	T cell subsets, platelets, monocytes		9-O-acetylated disialoyl group present on gangliosides, predominantly ganglioside D3
CD61	platelets, megakaryocytes, macrophages	110	integrin b3 subunit, associates with CD41 (GPIIb/IIIa) or CD51 (vitronectin receptor)		integrin b
CD62E	endothelium	140	endothelium leukocyte adhesion molecule (ELAM), bindssialyl-Lewis x, mediates rolling interaction of neutrophils on endothelium	ELAM-1, E-selectin	C type lectin, EGF and CCP superfamily
CD62L	B cells, T cells, monocytes, NK cells	150	leukocyte adhesion molecule (LAM), binds CD34, GlyCAM, mediates rolling interactions with endothelium	LAM-1, L-selectin, LECAM-1	C type lectin EGF and CCP superfamily
CD62P	platelets, megakaryocytes, endothelium	140	adhesion molecule, binds PSGL-1, mediates interaction of platelets with endothelial cells, monocytes and rolling interaction of leukocytes on endothelium	P-selectin, PADGEM	C type lectin EGF and CCP superfamily
CD63	activated platelets, monocytes, macrophages	53	unknown, is lysosomal membrane protein translocated to cell surface after activation	platelet activation antigen	Transmembrane 4 superfamily
CD64	monocytes, macrophages	72	high affinity receptor for IgG, binds IgG3>IgG1>IgG4>>>IgG2, mediates phagocytosis, antigen capture, ADCC	FcgRI	IgSF
CD65	myeloid cells		oligosaccharide component of a ceramide dodecasaccharide
CD66a	neutrophils	160-180	unknown, member of carcinoembryonic antigen (CEA) family (see below)	biliary glycoprotein-1 (BGP-1)	IgSF
CD66b	granulocytes	95-100	unknown, member of carcinoembryonic antigen (CEA) family	previously CD67	IgSF
CD66c	neutrophils, colon carcinoma	90	unknown, member of carcinoembryonic antigen (CEA) family	Nonspecific Crossreacting Antigen (NCA)	IgSF
CD66d	neutrophils	30	unknown, member of carcinoembryonic antigen (CEA) family		IgSF
CD66e，CD66f	adult colon epithelium, colon carcinoma	180-200	unknown, member of carcinoembryonic antigen (CEA) family	CarcinoEmbryonic Antigen (CEA)	IgSF
CD68	monocytes, macrophages, neutrophils, basophils, large lymphocytes	110	unknown	macrosialin
CD69	activated B cells, activated T cells, activated macrophages, activated NK cells	28, 32 homodimer	unknown, early activation antigen	Activation Inducer Molecule (AIM)	C-type lectin
CD70	activated B cells, activated T cells, macrophages	75,95,170	Ligand for CD27, may function in co-stimulation of B and T cells	Ki-24	TNF-like
CD71	All proliferating cells, hence activated leukocytes	95 homodimer	transferrin receptor	T9
CD72	B cells (not plasma cells)	42 homodimer	unknown, ligand for CD5	Lyb-2	C type lectin
CD73	B cell subsets, T cell subsets	69	ecto-5?-nucleotidase, dephosphorylates nucleotides to allow nucleoside uptake
CD74	B cells, macrophages, monocytes, MHC class II positive cells	33,35,41,43 (alternate initiation and splicing)	MHC class II associated Invariant chain	Ii, Ig
CD75	mature B cells, T cell subsets		sialoglycan moiety, ligand for CD22, mediates B cell/B cell adhesion
CD76	mature B cells, T cell subsets		a 2,6 sialylated polylactosamine expressed on glycosphingolilpids and glycoproteins
CD77	germinal center B cells		Neutral glycosphingolipid (Gala1?4Galb1?4Glcb1?ceramide), binds Shiga toxin, Crosslinking induces apoptosis	Globotriaocylceramide (Gb3), Pk blood group
Cdw78	B cells		unknown	Ba
CD79a,b	B cells	a: 40-45 b: 37	components of B cell antigen receptor analogous to CD3, required for cell surface expression and signal transduction	Iga, Igb	IgSF
CD80	B cell subset	60	costimulator, ligand for CD28 and CTLA-4	B7 (now B7-1), BB1	IgSF
CD81	lymphocytes	26	associates with CD19, CD21 to form B cell coreceptor	Target of AntiProliferative Antibody (TAPA-1)	Transmembrane 4 superfamily
CD82	leukocytes	50-53	unknown	R2	Transmembrane 4 superfamily
CD83	Activated B cells, activated T cells, circulating dendritic cells (veil cells)	43		HB15	IgSF
CDw84	monocytes, platelets, circulating B cells	73		GR6
CD85	monocytes, circulating B cells	120, 83		GR4
CD86	monocytes, activated B cells, dendritic cells	80	Ligand for CD28 and CTLA4	B7.2	IgSF
CD87	granulocytes, monocytes, macrophages, T cells, NK cells, wide variety of nonhematopioetic cell types	35-59	Receptor for urokinase plasminogen activator	uPAR	Ly-6 superfamily
CD88	polymorphonuclear leukocytes, macrophages, mast cells	43	Receptor for complement component C5a	C5aR	G protein complement receptor
CD89	monocytes, macrophages, granulocytes, neutrophils, B cell subsets, T cell subsets	50-70	IgA receptor	FcaR	IgSF
CD90	CD34+ prothymocytes (human) thymocytes, T cells (mouse)	18	unknown	Thy-1	IgSF
CD91	monocytes, many nonhematopoietic cells	515, 85 dimer	a2 macroglobulin receptor		EGF, LDL receptor superfamily
CDw92	neutrophils, monocytes, platelets, endothelium	70		GR9
CD93	neutrophils, monocytes, endothelium	120		GR11
CD94	T cell subsets, NK cells	43		KP43
CD95	wide variety of cell lines in vivodistribution uncertain	43	binds TNF-like ligand, induces apoptosis	Apo-1, Fas	NGF receptor superfamily
CD96	activated T cells, NK cells	160		T cell ACTivation Increased Late Expression (TACTILE)	IgSF
CD97	activated B and T cells, monocytes, granulocytes	75-85	Binds CD55	GR1	EGF, G protein complement receptor
CD98	T cells, B cells, NK cells, granulocytes, all human cell lines	80, 45 heterodimer	may be amino acid transporter	4F2, FRP-1
CD99	Peripheral blood lymphocytes, thymocytes	32	unknown	MIC2, E2
CD100	Hematopoietic cells	150 homodimer	unknown	GR3
CD101	monocytes, granulocytes, dendritic cells, activated T cells	120 homodimer	unknown	V7, BPC#4	IgSF
CD102	Resting lymphocytes, monocytes, vascular endothelial cells (strongest)	55-65	binds CD11a/CD18 (LFA-1) but not CD11b/CD18 (Mac-1)	ICAM-2	IgSF
CD103	Intraepithelial lymphocytes, 2-6% of peripheral blood lymphocytes	150,25	aE integrin	HML-1, a6,aE integrin	integrin a
CD104	CD4-CD8- thymocytes, neuronal, epithelial and some endothelial cells, Schwann cells, trophoblasts	220	integrin b4, associates with CD49f, binds laminins	b4 integrin	integrin b
CD105	Endothelial cells, activated monocytes and macrophages, bone marrow cell subsets	90 homodimer	Binds TGFb	Endoglin
CD106	Endothelial cells	100,110	Adhesion Molecule, ligand for VLA-4	VCAM-1	IgSF
CD107a	Activated platelets, activated T cells, activated neutrophils, activated endothelium	110	Unknown, is lysosomal protein translocated to the cell surface after activation	Lysosomal Associated Membrane Protein-1 (LAMP-1)
CD107b	Activated platelets, activated T cells, activated neutrophils, activated endothelium	120	Unknown, is lysosomal protein translocated to the cell surface after activation	LAMP-2
CDw108	Erythrocytes, circulating lymphocytes, lymphoblasts	80	unknown	GR2, John-Milton-Hagen blood group antigen
CD109	Activated T cells, activated platelets, vascular endothelium	170	unknown	Platelet activation factor, GR56
CD110-113	not yet assigned
CD114	Granulocytes, monocytes	95,139	Granulocyte colony stimulating factor (G-CSF) receptor	G-CSFR
CD115	monocytes, macrophages	150	Macrophage Colony Stimulating Factor (M-CSF) receptor	M-CSFR, c-fms	IgSF, tyrosine kinase
CD116	monocytes, neutrophils,eosinophils, endothelium	70-85	Granulocyte, Macrophage Colony Stimulating Factor (GM-CSF) receptor a chain	GM-CSFRa	cytokine receptor superfamily, fibronectin type III superfamily
CD117	hematopoietic progenitors	145	Stem Cell Factor (SCF) receptor	c-kit	IgSF tyrosine kinase
CD118	Broadly expressed		Interferon a, b receptor	IFNa,bR
CD119	marophages, monocytes, B cells, endothelium	90-100	Interferon g receptor	IFNgR
CD120a	hematopoietic and non-hematopoietic cells, highest on epithelial cells	50-60	TNF receptor, binds both TNFa and TNFb	TNFR-I	TNF receptor superfamily
CD120b	hematopoietic and non-hematopoietic cells, highest on myeloid cells	75-85	TNF receptor, binds both TNFa and TNFb	TNFR-II	TNF receptor superfamily
CD121a	thymocytes ,T cells	80	type I interleukin 1 receptor, binds IL-1a and IL-1b	IL-1R type I	IgSF
CDw121b	B cells, macrophages, monocytes	60-70	type II interleukin 1 receptor, binds IL-1a and IL-1b	IL-1R, ytpe II	IgSF
CD122	Natural Killer cells, resting T cell subsets, some B cell lines	75	IL-2 receptor b chain	IL-2Rb	cytokine receptor superfamily；fibronectin type III superfamily
CD123	Bone marrow stem cells, granulocytes, monocytes, megakaryocytes	70	IL-3 receptor a chain	IL-3R	cytokine receptor superfamily；fibronectin type III superfamily
CD124	Mature B and T cells, hematopoietic precursor cells	130-150	IL-4 receptor	IL-4R	cytokine receptor superfamily；fibronectin type III superfamily
CD125	Eosinophils, basophils, activated B cells	55-60	IL-5 receptor	IL-5R	cytokine receptor superfamily；fibronectin type III superfamily
CD126	Activated B cells and plasma cells, weak on most other leukocytes	80	IL-6 receptor a subunit	IL-6R	IgSF Cytokine receptor superfamily；fibronectin type III superfamily
CD127	Bone marrow lymphoid precursors, pro-B cells, mature T cells, monocytes	68-79, possibly forms homodimers	IL-7 receptor	IL-7R	fibronectin type III superfamily
CDw128	Neutrophils, basophils, T cell subsets	58-67	IL-8 receptor	IL-8R	G protein coupled receptor superfamily
CD129	Not yet assigned
CD130	Most cell types, strong on activated B cells and plasma cells	130	common subunit of IL-6, IL-11, oncostatin-M (OSM), and leukemia inhibitory factor (LIF) receptors	IL-6Rb, IL-11Rb, OSMRb, LIFRb	IgSF；Cytokine receptor superfamily；fibronectin type III superfamily
CDw131	Myeloid progenitors, granulocytes	140	common b subunit of IL-3, IL-5 and GM-CSF receptors	IL-3Rb, IL-5Rb, GM-CSFRb	cytokine receptor superfamily；fibronectin type III superfamily
CD132	B cells, T cells, NK cells, mast cells and neutrophils	64	IL-2 receptor g chain, common subunit of IL-2, IL-4, IL-7, IL-9, IL-15 receptors		cytokine receptor superfamily
CD134	activated T cells	50	may act as adhesion molecule, costimulator	OX40	TNF receptor superfamily
CD135	Multipotential precursors, myelomonocytic and B cell progenitors	130,155	growth factor receptor	FLK2, STK-1	tyrosine kinase
CDw136	Monocytes, epithelial cells, central and peripheral nervous system	180	chemotaxis, phagocytosis, cell growth and differentiation	MSP-R, RON	tyrosine kinase
CDw137	T and B lymphocytes, monocytes, some epithelial cells		costimulator of T cell proliferation	ILA (Induced by Lymphocyte Activation), 4-1BB	TNF receptor superfamily
CD138	B cells		heparan sulphate proteoglycan, binds collagen type I	Syndecan-1
CD139	B cells	209,228	unknown
CD140a,b	Stromal and some endothelial cells	Dimer。A: 180；b: 180	Platelet derived growth factor (PDGF) receptor alpha and beta chains	PDGFR
CD141	Vascular endothelial cells,	105	Anticoagulant, binds thrombin, the complex then activating protein C	Thrombomodulin, Fetomodulin	C-type lectin；EGF
CD142	Epidemal keratinocytes, various epithelial cells, astrocytes, Schwann cells. Absent from cells in direct contact with plasma unless induced by inflammatory mediators	45-47	Major initiating factor of clotting. Binds Factor VIIa ; this complex activates Factors VII, IX and X	Tissue Factor, thromboplastin	fibronectin type III superfamily
CD143	Endothelial cells, except large blood vessels and kidney, epithelial cells of brush borders of kidney and small intestine, neuronal cells, activated macrophages and some T cells. Soluble form in plasma.	170-180	Zn2+ metallopeptidase, dipeptidyl pedtidase, cleaves angiotensin I and bradykinin from precursor forms	Angiotensin converting enzyme (ACE)
CD144	Endothelial cells	135	Adhesion molecule, organises adherens junctions between endothelial cells	VE-cadherin	cadherin
CD145	Epithelial and some stromal cells	25,90,110	Unknown
CD146	Endothelium	130	potential adhesion molecule, localised at cell cell junctions	MCAM, MUC18,S-ENDO	IgSF
CD147	leukocytes, red blood cells, platelets, endothelial cells	55-65	potential adhesion molecule	M6, neurothelin, EMMPRIN, basigin, OX-47	IgSF
CD148	granulocytes, monocytes, dendritic cells, T cells, fibroblasts, nerve cells	240-260	contact inhibition of cell growth	HPTPh	fibronectin type III superfamily；protein tyrosine phosphatase
CD151	platelets, megakaryocytes, epithelial cells, endothelial cells	32	associates with b1 integrins	PETA-3, SFA-1	Transmembrane 4 superfamily
CD152	Activated T cells	33	Ligand for B7.1 (CD80), B7.2 (CD86); negative regulatior of T cell activation	CTLA4	IgSF
CD153	Activated T cells, activated macrophages, neutrophils, B cells	38-40	Ligand for CD30, may costimulate T cells	CD30L	TNF superfamily
CD154	Activated CD4 T cells	28,30.,33	Ligand for CD40, inducer of B cell proliferation and activation	CD40L, TRAP, T-BAM, gp39	TNF receptor family
CD155	Monocytes, macrophages, thymocytes, CNS neurons	80-90	normal function unknown; receptor for poliovirus	Poliovirus receptor	IgSF
CD156	neutrophils, monocytes	69	unknown, may be involved in leukocyte extravasation	MS2, ADAM 8 (A Disintegrin and Metalloprotease)
CD157	Granulocytes, monocytes, bone marrow stromal cells, vascular endothelial cells, follicular dendritic cells	42-45 (50 on monocytes)	ADP-ribosyl cyclase, cyclic ADP-ribose hydrolase	BST-1
CD158a	NK cell subsets	50 or 58	Inhibits NK cell cytotoxicity on binding MHC class I molecules	p50.1, p58.1	IgSF
CD158b	NK cell subsets	50 or 58	Inhibits NK cell cytotoxixity on binding HLA-Cw3 and related alleles	p50.2, p58.2	IgSF
CD161	NK cells, T cells	44	Regulates NK cytotoxicity	NKRP1	C type lectin
CD163	monocytes, macrophages	130	unknown	M130
CD166	Activated T cells, thymic epithelium, fibroblasts,neurons,.	100-105	ligand for CD6, involved in neurite extension	ALCAM, BEN, DM-GRASP, SC-1	IgSF

回答者：dedaokuaile16

很好，但是能否把各个标记的表达、功能更详细些呢？尤其是表达说明细胞处于哪个阶段、处于什么状态、具有什么功能体现出来就更好了。

2009年8月12日 0:54