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标题：用CD44和CD54来区分Burkitt淋巴瘤和CD10 的DLBCL Am J Clin Pathol. 2010 May;133(5):718-26.
A novel flow cytometric antibody panel for distinguishing Burkitt lymphoma from CD10+ diffuse large B-cell lymphoma.
Schniederjan SD, Li S, Saxe DF, Lechowicz MJ, Lee KL, Terry PD, Mann KP.
Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA.
Abstract
Rapid and accurate differential diagnosis between Burkitt lymphoma (BL) and CD10+ diffuse large B-cell lymphoma (DLBCL) is imperative because their treatment differs. Recent studies have characterized several antigens differentially expressed in these 2 types of lymphoma. Our goal was to determine whether use of these markers would aid in the differential diagnosis of BL vs CD10+ DLBCL by flow cytometric immunophenotyping (FCI). Twenty-three cases of CD10+ B-cell lymphomas with available cryopreserved samples were identified (13 BL and 10 CD10+ DLBCL). Multiparameter FCI was performed using the following antibodies: CD18, CD20, CD43, CD44, and CD54 and isotype controls. Expression of CD44 and CD54 was detected at a significantly lower level in BL compared with CD10+ DLBCL (P = .001 and P = .01, respectively). There was not a significant difference in expression of CD18 and CD43. Our data show that expression of CD44 and CD54 differs significantly between BL and CD10+ DLBCL.
PMID: 20395518 [PubMed - indexed for MEDLINE]
MeSH Terms:
- Adult
- Aged
- Antibodies, Monoclonal/immunology*
- Antibodies, Neoplasm/immunology*
- Burkitt Lymphoma/immunology
- Burkitt Lymphoma/metabolism
- Burkitt Lymphoma/pathology*
- Child, Preschool
- Diagnosis, Differential
- Female
- Flow Cytometry/methods*
- Humans
- Immunophenotyping
- Lymphoma, Large B-Cell, Diffuse/immunology
- Lymphoma, Large B-Cell, Diffuse/metabolism
- Lymphoma, Large B-Cell, Diffuse/pathology*
- Male
- Middle Aged
- Neprilysin/metabolism*
- Tumor Markers, Biological/metabolism
Substances:
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发表于 2010-8-1 20:56:06
